The multi-factorial nature of clinical multidrug resistance in cancer

YG Assaraf, A Brozovic, AC Gonçalves… - Drug resistance …, 2019 - Elsevier
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

The impact of comorbidity on cancer and its treatment

D Sarfati, B Koczwara, C Jackson - CA: a cancer journal for …, 2016 - Wiley Online Library
Answer questions and earn CME/CNE Comorbidity is common among cancer patients and,
with an aging population, is becoming more so. Comorbidity potentially affects the …

Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

A comparison of five common drug–drug interaction software programs regarding accuracy and comprehensiveness

R Kheshti, M Aalipour, S Namazi - Journal of research in …, 2016 - journals.lww.com
Objective: Drug–drug interactions (DDIs) can cause failure in treatment and adverse events.
DDIs screening software is an important tool to aid clinicians in the detection and …

Drug-drug interaction software in clinical practice: a systematic review

T Roblek, T Vaupotic, A Mrhar, M Lainscak - European journal of clinical …, 2015 - Springer
Purpose Several electronic databases which report the prevalence of drug-drug interactions
(DDIs) are used as a tool for evaluation of potentially harmful DDIs. The aim of our review …

The randomized AMBORA trial: Impact of pharmacological/pharmaceutical care on medication safety and patient-reported outcomes during treatment with new oral …

P Dürr, K Schlichtig, C Kelz, B Deutsch… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Oral anticancer drugs (eg, kinase inhibitors) play an important role in cancer
therapy. However, considerable challenges regarding medication safety of oral anticancer …

Clinical pharmacokinetics and pharmacodynamics of bortezomib

CRC Tan, S Abdul-Majeed, B Cael, SK Barta - Clinical pharmacokinetics, 2019 - Springer
Proteasome inhibitors disrupt multiple pathways in cells and the bone marrow
microenvironment, resulting in apoptosis and inhibition of cell-cycle progression …

[HTML][HTML] Drug–drug interactions in patients treated for cancer: a prospective study on clinical interventions

RWF van Leeuwen, FGA Jansman… - Annals of …, 2015 - Elsevier
Drug interactions are of major concern, since cancer patients take many medications and
may have serious consequences. Therefore, a study was designed to identify interactions …

Prevalence and significance of potential drug-drug interactions among cancer patients receiving chemotherapy

M Ismail, S Khan, F Khan, S Noor, H Sajid, S Yar… - BMC cancer, 2020 - Springer
Background Cancer patients often receive multiple drugs to maximize their therapeutic
benefit, treat co-morbidities and counter the adverse effects of chemotherapy. Concomitant …

Recent developments in photodynamic therapy and its application against multidrug resistant cancers

D Bhattacharya, M Mukhopadhyay, K Shivam… - Biomedical …, 2023 - iopscience.iop.org
Recently, photodynamic therapy (PDT) has received a lot of attention for its potential use in
cancer treatment. It enables the therapy of a multifocal disease with the least amount of …