Since the introduction of cisplatin to oncology in 1978, Pt (II) and Pd (II) compounds have
been intensively studied with a view to develop the improved anticancer agents. Polynuclear …

Taurine, a cysteine-derived zwitterionic sulfonic acid, is a common ingredient in energy
drinks and is naturally found in fish and other seafood. In humans, taurine is produced …

Resistance to clinical therapies remains a major barrier in cancer management. There is a
critical need for rapid and highly sensitive diagnostic tools that enable early prediction of …

Despite numerous screening tools for colorectal cancer (CRC), 25% of patients are
diagnosed with advanced disease. Novel diagnostic technologies that are early, accurate …

Background: Because of the interplay between mitochondrial respiration and cellular
metabolism, the simultaneous monitoring of both cellular processes provides important …

Pt-Based drugs play a very important role in current cancer treatments; yet, their cellular and
mechanistic aspects are not fully understood. NMR metabolomics provides a powerful tool to …

Studies of drug–cell interactions in cancer model systems are essential in the preclinical
stage of rational drug design, which relies on a thorough understanding of the mechanisms …

The interaction of the widely used anticancer drug cisplatin with DNA bases was studied by
EXAFS and vibrational spectroscopy (FTIR, Raman and INS), coupled with DFT/plane-wave …

Increasing evidence suggests a critical role of lipids in both the mechanisms of toxicity and
resistance of cells to platinum (II) complexes. In particular, cisplatin and other analogues …

1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in
combination with multivariate statistical analyses to study the metabolic response of whole …