Mitochondrial management of reactive oxygen species

G Napolitano, G Fasciolo, P Venditti - Antioxidants, 2021 - mdpi.com
Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Vitamin C and immune cell function in inflammation and cancer

A Ang, JM Pullar, MJ Currie… - Biochemical Society …, 2018 - portlandpress.com
Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …

Connections between TET proteins and aberrant DNA modification in cancer

Y Huang, A Rao - Trends in Genetics, 2014 - cell.com
DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …

[HTML][HTML] Vitamin C: From nutrition to oxygen sensing and epigenetics

T Kietzmann - Redox Biology, 2023 - Elsevier
Vitamin C is unbeatable-at least when it comes to sales. Of all the vitamin preparations,
those containing vitamin C sell best. This is surprising because vitamin C deficiency is …

Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics

CD′ Aniello, F Cermola, EJ Patriarca… - Stem cells …, 2017 - Wiley Online Library
Transcription factors and signaling molecules are well‐known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …

Glucose metabolism and dynamics of facilitative glucose transporters (GLUTs) under the influence of heat stress in dairy cattle

Z Abbas, A Sammad, L Hu, H Fang, Q Xu, Y Wang - Metabolites, 2020 - mdpi.com
Heat stress is one of the main threats to dairy cow production; in order to resist heat stress,
the animal exhibits a variety of physiological and hormonal responses driven by complex …

Vitamin C as a Modulator of the Response to Cancer Therapy

W Blaszczak, W Barczak, J Masternak, P Kopczyński… - Molecules, 2019 - mdpi.com
Ascorbic acid (vitamin C) has been gaining attention as a potential treatment for human
malignancies. Various experimental studies have shown the ability of pharmacological …

Targeting reactive oxygen species capacity of tumor cells with repurposed drug as an anticancer therapy

J Wang, D Sun, L Huang, S Wang… - Oxidative medicine and …, 2021 - Wiley Online Library
Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are
associated with cancer initiation, growth, and response to therapies. As concentrations …

Neurobiology of vitamin C: Expanding the focus from antioxidant to endogenous neuromodulator

SJ Ballaz, GV Rebec - Pharmacological research, 2019 - Elsevier
Ascorbic acid (AA) is a water-soluble vitamin (C) found in all bodily organs. Most mammals
synthesize it, humans are required to eat it, but all mammals need it for healthy functioning …

Glucose transport and transporters in the endomembranes

B Lizák, A Szarka, Y Kim, K Choi, CE Németh… - International Journal of …, 2019 - mdpi.com
Glucose is a basic nutrient in most of the creatures; its transport through biological
membranes is an absolute requirement of life. This role is fulfilled by glucose transporters …