The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

The noncanonical pathway for in vivo nitric oxide generation: the nitrate-nitrite-nitric oxide pathway

V Kapil, RS Khambata, DA Jones, K Rathod… - Pharmacological …, 2020 - ASPET
In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Red blood cell function and dysfunction: redox regulation, nitric oxide metabolism, anemia

V Kuhn, L Diederich, TCS Keller IV… - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway

S Lidder, AJ Webb - British journal of clinical pharmacology, 2013 - Wiley Online Library
The discovery that dietary (inorganic) nitrate has important vascular effects came from the
relatively recent realization of the 'nitrate‐nitrite‐nitric oxide (NO) pathway'. Dietary nitrate …

Novel aspects of dietary nitrate and human health

E Weitzberg, JO Lundberg - Annual review of nutrition, 2013 - annualreviews.org
The circulation of nitrogen in nature is a prerequisite for life on earth. In the nitrogen cycle
atmospheric nitrogen is fixated by bacteria into forms that can be utilized by plants and …

[HTML][HTML] How biology handles nitrite

LB Maia, JJG Moura - Chemical Reviews, 2014 - ACS Publications
Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Roles of dietary inorganic nitrate in cardiovascular health and disease

JO Lundberg, M Carlström, FJ Larsen… - Cardiovascular …, 2011 - academic.oup.com
Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo
generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate …

Red blood cell dysfunction: a new player in cardiovascular disease

J Pernow, A Mahdi, J Yang, Z Zhou - Cardiovascular research, 2019 - academic.oup.com
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

Structure, function and applications of carbonic anhydrase isozymes

MI Hassan, B Shajee, A Waheed, F Ahmad… - Bioorganic & medicinal …, 2013 - Elsevier
The carbonic anhydrases enzymes (CAs, EC 4.2. 1.1) are zinc containing metalloproteins,
which efficiently catalyse the reversible conversion of carbon dioxide to bicarbonate and …