Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors

WH Ip, MH Tatham, S Krohne, J Gruhne… - Journal of …, 2023 - Am Soc Microbiol
The human adenovirus species C type 5 (HAdV-C5) early region 1B 55 kDa (E1B-55K)
protein is a multifunctional protein that promotes viral replication and adenovirus-mediated …

The Cajal body protein p80-coilin forms a complex with the adenovirus L4-22K protein and facilitates the nuclear export of adenovirus mRNA

L White, B Erbay, GE Blair - Mbio, 2023 - Am Soc Microbiol
Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human
adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of …

Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A

N Sun, J Zhang, C Zhang, T Xie, Z Zhang… - Journal of …, 2023 - Am Soc Microbiol
Human adenovirus (HAdV) is ubiquitous in the human population, constituting a significant
burden of global respiratory diseases. Children and individuals with low immunity are at risk …

E1B-55K is a phosphorylation-dependent transcriptional and posttranscriptional regulator of viral gene expression in human adenovirus C5 infection

P Hidalgo, Y Garcés, E Mundo, RE López… - Journal of …, 2022 - Am Soc Microbiol
The multifunctional adenoviral E1B-55K phosphoprotein is a major regulator of viral
replication and plays key roles in virus-mediated cell transformation. While much is known …

Adenovirus remodeling of the host proteome and host factors associated with viral genomes

JM Dybas, KK Lum, K Kulej, ED Reyes, R Lauman… - Msystems, 2021 - Am Soc Microbiol
Viral infections are associated with extensive remodeling of the cellular proteome. Viruses
encode gene products that manipulate host proteins to redirect cellular processes or subvert …

The human adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53

L Göttig, S Jummer, L Staehler, P Groitl… - Journal of …, 2024 - Am Soc Microbiol
Human adenoviruses (HAdV) are classified as DNA tumor viruses due to their potential to
mediate oncogenic transformation in non-permissive mammalian cells and certain human …

Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis

DF Edwards, III, EA Pereira, LA Castro-Jorge… - Journal of …, 2024 - journals.asm.org
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by
autophosphorylation in response to double strand DNA (dsRNA) and other stimuli. Activated …

Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism

Z Hajikhezri, Y Kaira, E Schubert, M Darweesh… - Journal of …, 2023 - Am Soc Microbiol
Human adenoviruses (HAdVs) are widespread pathogens causing a variety of diseases. A
well-controlled expression of virus capsid mRNAs originating from the major late …

Nuclear ribonucleoprotein RALY downregulates foot-and-mouth disease virus replication but antagonized by viral 3C protease

J Wu, C Sun, J Guan, SW Abdullah, X Wang… - Microbiology …, 2024 - Am Soc Microbiol
The internal ribosome entry site (IRES) element constitutes a cis-acting RNA regulatory
sequence that recruits the ribosomal initiation complex in a cap-independent manner …

Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

B Tejera-Hernández, DE Goodman… - Journal of …, 2022 - Am Soc Microbiol
Protein kinase R (PKR) is a cellular kinase involved in the antiviral response. The
inactivation or inhibition of this protein is a conserved activity in DNA and RNA virus …