Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Mitochondrial diseases affect one in 2,000 individuals; they can present at any age and they
can manifest in any organ. How defects in mitochondria can cause such a diverse range of …

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across
diverse areas of biology and medicine. The recognition of mitochondria as a major …

Inherited disorders of oxidative phosphorylation cause the clinically and genetically
heterogeneous diseases known as mitochondrial energy generation disorders, or …

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …

Post-transcriptional RNA modifications, the epitranscriptome, play important roles in
modulating the functions of RNA species. Modifications of rRNA are key for ribosome …

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome,
a by‐product of an ancient endosymbiotic event, mitochondria maintains a specialized and …

The synthesis of all 13 mitochondrial DNA (mtDNA)-encoded protein subunits of the human
oxidative phosphorylation (OXPHOS) system is carried out by mitochondrial ribosomes …