Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities
TK Kim, EN Vandsemb, RS Herbst… - Nature Reviews Drug …, 2022 - nature.com
Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …
Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy
Y Wu, M Yi, M Niu, Q Mei, K Wu - Molecular cancer, 2022 - Springer
The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
Harnessing nanomaterials for cancer sonodynamic immunotherapy
Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …
However, such emerging therapy still suffers from the low response rates and immune …
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
A challenge in oncology is to rationally and effectively integrate immunotherapy with
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
Summary RNA N 6-methyladenosine (m 6 A) modification is implicated in cancer
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
Cancer nanomedicine for combination cancer immunotherapy
Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury
Acute exposure to high-dose gamma radiation due to radiological disasters or cancer
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …
radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute …
Using immunotherapy to boost the abscopal effect
More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …
of metastatic cancer at distant sites that are not irradiated was described and called the …
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
C Vanpouille-Box, A Alard, MJ Aryankalayil… - Nature …, 2017 - nature.com
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy.
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …
However, the mechanisms by which radiation induces anti-tumour T cells remain unclear …
Combination cancer therapy with immune checkpoint blockade: mechanisms and strategies
SA Patel, AJ Minn - Immunity, 2018 - cell.com
The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …
has changed the treatment paradigm in oncology. However, combination therapies with …