Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

L Abenavoli, AA Izzo, N Milić, C Cicala… - Phytotherapy …, 2018 - Wiley Online Library
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …

Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

Гепатопротекторы

СВ Оковитый, ВА Приходько, НН Безбородкина… - 2022 - elibrary.ru
В настоящем издании проанализированы и систематизированы сведения по
клиническому применению лекарственных средств, для которых гепатотропное …

The potential application of chinese medicine in liver diseases: a new opportunity

K Fu, C Wang, C Ma, H Zhou, Y Li - Frontiers in Pharmacology, 2021 - frontiersin.org
Liver diseases have been a common challenge for people all over the world, which
threatens the quality of life and safety of hundreds of millions of patients. China is a major …

A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice

R Feng, JH Chen, CH Liu, FB Xia, Z Xiao, X Zhang… - Phytomedicine, 2019 - Elsevier
Background Excess alcohol exposure leads to alcoholic liver disease (ALD). Pueraria lobata
(PUE) and Silybum marianum (SIL) are two well-known hepatoprotective herbal remedies …

Attenuation of benzo [a] pyrene-induced oxidative stress and cell apoptosis in albino rats by wild milk thistle (Silybum Marianum L.) seeds extract

MZ Mahran, Y El-Hassanen - Egyptian Journal of Chemistry, 2023 - journals.ekb.eg
Oxidative stress (OS) is considered a pathogenic mechanism that, if not strictly controlled,
triggers the onset and progression of many chronic and degenerative diseases. This …

Hesperitin attenuates alcoholic steatohepatitis by regulating TLR4/NF-κB signaling in mice

F Yuan, G Xia, J Cai, X Lv, M Dai - Analytical Biochemistry, 2023 - Elsevier
In the peel of citrus (Rutaceae) fruit, hesperitin (Hesp), a flavanone glycoside chemical, is
found naturally. Hesp has been found to have a wide range of pharmacological actions …

Silymarin protects the liver from α-naphthylisothiocyanate-induced cholestasis by modulating the expression of genes involved in bile acid homeostasis: Anti …

I Sohail, N Malkani, N Tahir, A Khalil, R Attar… - Cellular and Molecular …, 2022 - cellmolbiol.org
Cholestasis is characterized by impaired bile flow which results in inflammation, cirrhosis,
and ultimately liver failure. The current study is aimed to evaluate the anti-cholestatic effect …

[HTML][HTML] Комбинированное применение гепатопротекторов

СВ Оковитый - Лечащий врач, 2020 - cyberleninka.ru
При всей полиэтиологичности повреждений печени сходство основных звеньев
патогенеза позволяет использовать достаточно близкую патогенетическую терапию …

Silybum marianum (milk thistle) improves vancomycin induced nephrotoxicity by downregulating apoptosis

N Malkani, A Naeem, F Ijaz, S Mumtaz, S Ashraf… - Molecular Biology …, 2020 - Springer
Increased use of vancomycin for treating infections, and the associated risk of causing
nephrotoxicity lead to the present study. The antioxidant and anti-apoptotic potential of …