Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy, with an estimated 35% lifetime risk in this patient population. There …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Background: The right ventricular outflow tract (RVOT) is acknowledged to be responsible
for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains …

BACKGROUND: L-type calcium channel (LTCC) mutations have been associated with
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …

Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …

Background Brugada syndrome (BrS) is considered to be an inherited arrhythmic disease
associated with fatal complications and premature sudden unexpected death. The …

The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …

Brugada syndrome (BrS) is a condition defined by ST-segment alteration in right precordial
leads and a risk of sudden death. Because BrS is often associated with right bundle branch …

ZFHX3) have been identified as common susceptibility genes for AF in European and
Japanese populations. 26 Most importantly, AF is strongly associated with an approximately …

Background—Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene,
which encodes the α-subunit of the cardiac sodium channel Nav1. 5. However,≈ 20% of …