[HTML][HTML] Recommendations for improving statistical inference in population genomics
The field of population genomics has grown rapidly in response to the recent advent of
affordable, large-scale sequencing technologies. As opposed to the situation during the …
affordable, large-scale sequencing technologies. As opposed to the situation during the …
On the prospect of achieving accurate joint estimation of selection with population history
As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …
variation, disentangling the contributions of each has remained as a major challenge in …
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
[HTML][HTML] Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
High quality reference genomes are crucial to understanding genome function, structure and
evolution. The availability of reference genomes has allowed us to start inferring the role of …
evolution. The availability of reference genomes has allowed us to start inferring the role of …
Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome
S Liu, L Zhang, Y Sang, Q Lai, X Zhang… - Molecular biology …, 2022 - academic.oup.com
Hybridization and resulting introgression are important processes shaping the tree of life
and appear to be far more common than previously thought. However, how the genome …
and appear to be far more common than previously thought. However, how the genome …
[HTML][HTML] An approximate full-likelihood method for inferring selection and allele frequency trajectories from DNA sequence data
Most current methods for detecting natural selection from DNA sequence data are limited in
that they are either based on summary statistics or a composite likelihood, and as a …
that they are either based on summary statistics or a composite likelihood, and as a …
The impact of purifying and background selection on the inference of population history: problems and prospects
Current procedures for inferring population history generally assume complete neutrality—
that is, they neglect both direct selection and the effects of selection on linked sites. We here …
that is, they neglect both direct selection and the effects of selection on linked sites. We here …
Background selection and FST: Consequences for detecting local adaptation
R Matthey‐Doret, MC Whitlock - Molecular ecology, 2019 - Wiley Online Library
Background selection is a process whereby recurrent deleterious mutations cause a
decrease in the effective population size and genetic diversity at linked loci. Several authors …
decrease in the effective population size and genetic diversity at linked loci. Several authors …
[HTML][HTML] Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation
Natural selection leaves distinct signatures in the genome that can reveal the targets and
history of adaptive evolution. By analysing high-coverage genome sequence data from 4 …
history of adaptive evolution. By analysing high-coverage genome sequence data from 4 …
Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements
Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …