Endoplasmic reticulum stress in liver diseases

A Ajoolabady, N Kaplowitz, C Lebeaupin, G Kroemer… - Hepatology, 2023 - journals.lww.com
The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding
of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes …

[HTML][HTML] Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal …

J Sharifi-Rad, YE Rayess, AA Rizk, C Sadaka… - Frontiers in …, 2020 - frontiersin.org
Curcumin, a yellow polyphenolic pigment from the Curcuma longa L.(turmeric) rhizome, has
been used for centuries for culinary and food coloring purposes, and as an ingredient for …

Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives

XY Xu, X Meng, S Li, RY Gan, Y Li, HB Li - Nutrients, 2018 - mdpi.com
Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used
as a spice in cooking and a yellow pigment in the food processing industry. Recent studies …

Curcumin Inhibits the PERK‐eIF2α‐CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress‐induced Rat Chondrocytes and Ameliorates …

K Feng, Y Ge, Z Chen, X Li, Z Liu, X Li… - Oxidative Medicine …, 2019 - Wiley Online Library
Oxidative stress plays a crucial role in the occurrence and development of osteoarthritis (OA)
through the activation of endoplasmic reticulum (ER) stress. Curcumin is a polyphenolic …

Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: therapeutic targets for obesity and type 2 diabetes

K Aamir, HU Khan, G Sethi, MA Hossain… - Pharmacological …, 2020 - Elsevier
Diabesity is the combination of type 2 diabetes and obesity characterized by chronic low-
grade inflammation. The Wnt signaling act as an evolutionary pathway playing crucial role in …

Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation

R Afrin, S Arumugam, A Rahman, MII Wahed… - International …, 2017 - Elsevier
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as
antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the …

Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways

A Shakeri, MR Zirak, AW Hayes, R Reiter… - Pharmacological …, 2019 - Elsevier
The endoplasmic reticulum (ER), a cellular organelle with multiple functions, plays an
important role in several biological processes including protein folding, secretion, lipid …

[HTML][HTML] Utility of curcumin for the treatment of diabetes mellitus: evidence from preclinical and clinical studies

S Rivera-Mancía, J Trujillo, JP Chaverri - Journal of Nutrition & Intermediary …, 2018 - Elsevier
Turmeric or Curcuma longa is a natural product, whose medicinal properties have been
extensively studied and a wide variety of therapeutic effects on several diseases such as …

Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis

IRSR Dias, HH Lo, K Zhang, BYK Law, AA Nasim… - Pharmacological …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which affects about
0.5–1% of people with symptoms that significantly impact a sufferer's lifestyle. The cells …

Turmeric: A review of its chemical composition, quality control, bioactivity, and pharmaceutical application

FC Meng, YQ Zhou, D Ren, R Wang, C Wang… - Natural and artificial …, 2018 - Elsevier
Turmeric (the rhizome of Curcuma longa Linn.) has been used as a spice, food flavoring and
coloring agent, and in medicinal preparations for various diseases including cough, diabetic …