Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer …

Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

Since the 1970s, the epidemic of hepatocellular carcinoma (HCC) has spread beyond the
Eastern Asian predominance and has been increasing in Northern hemisphere, especially …

Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Abstract Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer
deaths in the United States alone. The public health burden associated with these numbers …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …

In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …

Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …

Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …