Globally, cardiovascular diseases (CVDs) are the number one cause of mortality.
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …

Bioactive lipid mediators resulting from the metabolism of polyunsaturated fatty acids (PUFA)
are controlled by many pathways that regulate the levels of these mediators and maintain …

Lipid mediators are produced from the oxidation of polyunsaturated fatty acids through
enzymatic and free radical-mediated reactions. When subject to oxygenation via …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

Oxylipins are lipid mediators produced from polyunsaturated fatty acid (PUFA) metabolism,
and are thought to be a molecular explanation for the diverse biological effects of PUFAs …

Inflammation plays a crucial role in the initiation and development of a wide range of
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …

Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …

Chronic and uncleared inflammation is the root cause of various cardiovascular diseases.
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …