Role of oxylipins in cardiovascular diseases
MA Nayeem - Acta Pharmacologica Sinica, 2018 - nature.com
Globally, cardiovascular diseases (CVDs) are the number one cause of mortality.
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …
Epoxy fatty acids are promising targets for treatment of pain, cardiovascular disease and other indications characterized by mitochondrial dysfunction, endoplasmic …
C McReynolds, C Morisseau, K Wagner… - … lipid signaling pathways, 2020 - Springer
Bioactive lipid mediators resulting from the metabolism of polyunsaturated fatty acids (PUFA)
are controlled by many pathways that regulate the levels of these mediators and maintain …
are controlled by many pathways that regulate the levels of these mediators and maintain …
[HTML][HTML] Lipidomics of oxidized polyunsaturated fatty acids
KA Massey, A Nicolaou - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid mediators are produced from the oxidation of polyunsaturated fatty acids through
enzymatic and free radical-mediated reactions. When subject to oxygenation via …
enzymatic and free radical-mediated reactions. When subject to oxygenation via …
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease
I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
An overview of the biologic effects of omega-6 oxylipins in humans
GC Shearer, RE Walker - Prostaglandins, Leukotrienes and Essential Fatty …, 2018 - Elsevier
Oxylipins are lipid mediators produced from polyunsaturated fatty acid (PUFA) metabolism,
and are thought to be a molecular explanation for the diverse biological effects of PUFAs …
and are thought to be a molecular explanation for the diverse biological effects of PUFAs …
CYP450 epoxygenase metabolites, epoxyeicosatrienoic acids, as novel anti-inflammatory mediators
Z Shi, Z He, DW Wang - Molecules, 2022 - mdpi.com
Inflammation plays a crucial role in the initiation and development of a wide range of
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …
Cytochrome P450-derived eicosanoids and heart function
KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …
enzymes, which are important in the metabolism of foreign and endogenous compounds …
The role of epoxyeicosatrienoic acids in cardiac remodeling
J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
Dietary modulation of oxylipins in cardiovascular disease and aging
SPB Caligiuri, M Parikh… - American Journal …, 2017 - journals.physiology.org
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …
Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure
A Rao, A Gupta, V Kain… - American Journal of …, 2023 - journals.physiology.org
Chronic and uncleared inflammation is the root cause of various cardiovascular diseases.
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …
Fundamentally, acute inflammation is supportive when overlapping with safe clearance of …