Spontaneous respiratory effort during mechanical ventilation has long been recognized to
improve oxygenation, and because oxygenation is a key management target, such effort …

COVID-19 pneumonia is associated with hypoxaemic respiratory failure, ranging from mild
to severe. Because of the worldwide shortage of ICU beds, a relatively high number of …

Purpose Experimental animal models of acute respiratory distress syndrome (ARDS) have
shown that the updated airway pressure release ventilation (APRV) methodologies may …

Optimizing gas exchange, avoiding lung injury, and preserving respiratory muscle strength
and endurance are vital therapeutic objectives for managing acute lung injury. Accordingly …

Acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas
exchange. Hypoxemia is mainly due to intrapulmonary shunt, whereas increased alveolar …

Noninvasive ventilation (NIV) has a number of physiologic effects similar to invasive
ventilation. The major effects are to augment minute ventilation and reduce muscle loading …

Rationale: Spontaneous breathing during mechanical ventilation increases transpulmonary
pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary …

BACKGROUND: The efficacy of noninvasive oxygenation strategies (NIOS) in treating
COVID-19 disease is unknown. We conducted a prospective observational study to assess …

We update and summarize the role of spontaneous breathing during mechanical ventilation
in ARDS, which can be beneficial or deleterious, depending on the strength of spontaneous …

ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This
heterogeneity at least partially explains the difficulty in studying treatments for these patients …