Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

Abstract “Genomically” humanized animals are invaluable tools for generating human
disease models and for biomedical research. Humanized animal models have generally …

Growing evidence supports the implication of DYRK1A in the development of cognitive
deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate …

Progress in earlier detection and clinical management has increased life expectancy and
quality of life in people with Down syndrome (DS). However, no drug has been approved to …

Alzheimer's disease is connected to a number of other neurodegenerative conditions,
known collectively as 'tauopathies', by the presence of aggregated tau protein in the brain …

Huntingtin (HTT)-lowering therapies show great promise in treating Huntington's disease.
We have developed a microRNA targeting human HTT that is delivered in an adeno …

With increasingly large numbers of mouse models of human disease dedicated to MRI
studies, compromises between in vivo and ex vivo MRI must be fully understood in order to …

Brain volume measurements extracted from structural MRI data sets are a widely accepted
neuroimaging biomarker to study mouse models of neurodegeneration. Whether to acquire …

Down syndrome (DS) is one of the most common birth defects and the most prevalent
genetic form of intellectual disability. DS arises from trisomy of chromosome 21, but its …

Small-mammal neuroimaging offers incredible opportunities to investigate structural and
functional aspects of the brain. Many tools have been developed in the last decade to …