Natural products have represented attractive alternatives for disease prevention and
treatment over the course of human history and have contributed to the development of …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

What is known and objective Numerous population pharmacokinetic studies of theophylline
have been conducted in paediatric and adult patients. The purpose of this review was to …

Abstract Background Genetic variations in Idiopathic Pulmonary Fibrosis (IPF) affect survival
and outcomes. Current antifibrotic agents are managed based on the patient's reported side …

Background To analyze the allelic variants of genes of enzymes involved in estrogen
metabolism: CYP1A1, CYP1A2, CYP19 and SULT1A1 using polymerase chain reaction …

This study was designed to investigate the impact of cytochrome P 450 (CYP) 1 A 2
polymorphisms on theophylline metabolism in a non‐smoking healthy male Chinese …

Genetic variations in cytochrome P450 1A2 (CYP1A2) are associated with interindividual
variability in the metabolism and efficacy of many medications. Twenty CYP1A2 variants …

Tuberculosis affects 10 million people and over 320,000 South Africans every year. A
significant proportion of patients treated for tuberculosis develop post-tuberculous lung …

Objectives: The aim of this study was to investigate the population pharmacokinetics of
theophylline in premature Korean infants and to assess the influence of clinical covariates …