Next-generation DNA sequencing methods

ER Mardis - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Recent scientific discoveries that resulted from the application of next-generation DNA
sequencing technologies highlight the striking impact of these massively parallel platforms …

Back to the future: museum specimens in population genetics

P Wandeler, PEA Hoeck, LF Keller - Trends in ecology & evolution, 2007 - cell.com
Museums and other natural history collections (NHC) worldwide house millions of
specimens. With the advent of molecular genetic approaches these collections have …

Late Quaternary dynamics of Arctic biota from ancient environmental genomics

Y Wang, MW Pedersen, IG Alsos, B De Sanctis… - Nature, 2021 - nature.com
During the last glacial–interglacial cycle, Arctic biotas experienced substantial climatic
changes, yet the nature, extent and rate of their responses are not fully understood …

A draft sequence of the Neandertal genome

RE Green, J Krause, AW Briggs, T Maricic, U Stenzel… - science, 2010 - science.org
Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …

[HTML][HTML] Complete genomes reveal signatures of demographic and genetic declines in the woolly mammoth

E Palkopoulou, S Mallick, P Skoglund, J Enk… - Current Biology, 2015 - cell.com
The processes leading up to species extinctions are typically characterized by prolonged
declines in population size and geographic distribution, followed by a phase in which …

Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA

AW Briggs, U Stenzel, M Meyer, J Krause… - Nucleic acids …, 2010 - academic.oup.com
ABSTRACT DNA sequences determined from ancient organisms have high error rates,
primarily due to uracil bases created by cytosine deamination. We use synthetic …

The derived FOXP2 variant of modern humans was shared with Neandertals

J Krause, C Lalueza-Fox, L Orlando, W Enard… - Current biology, 2007 - cell.com
Although many animals communicate vocally, no extant creature rivals modern humans in
language ability. Therefore, knowing when and under what evolutionary pressures our …

[HTML][HTML] A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing

RE Green, AS Malaspinas, J Krause, AW Briggs… - Cell, 2008 - cell.com
A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old
Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA …

Analysis of one million base pairs of Neanderthal DNA

RE Green, J Krause, SE Ptak, AW Briggs, MT Ronan… - Nature, 2006 - nature.com
Neanderthals are the extinct hominid group most closely related to contemporary humans,
so their genome offers a unique opportunity to identify genetic changes specific to …

Pleistocene rewilding: an optimistic agenda for twenty-first century conservation

C Josh Donlan, J Berger, CE Bock… - The American …, 2006 - journals.uchicago.edu
Large vertebrates are strong interactors in food webs, yet they were lost from most
ecosystems after the dispersal of modern humans from Africa and Eurasia. We call for …