Evaluation of the use of therapeutic peptides for cancer treatment

S Marqus, E Pirogova, TJ Piva - Journal of biomedical science, 2017 - Springer
Cancer along with cardiovascular disease are the main causes of death in the industrialised
countries around the World. Conventional cancer treatments are losing their therapeutic …

Anticancer peptides mechanisms, simple and complex

P Norouzi, M Mirmohammadi, MHH Tehrani - Chemico-Biological …, 2022 - Elsevier
Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …

FOXO factors and breast cancer: outfoxing endocrine resistance

M Bullock - Endocrine-related cancer, 2016 - erc.bioscientifica.com
Four cardiac hormones, namely atrial natriuretic peptide, vessel dilator, kaliuretic peptide,
and long-acting natriuretic peptide, reduce up to 97% of all cancer cells in vitro. These four …

ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling

LJ Guo, AA Alli, DC Eaton… - American Journal of …, 2013 - journals.physiology.org
Epithelial sodium channels (ENaCs) located at the apical membrane of polarized epithelial
cells are regulated by the second messenger guanosine 3′, 5′-cyclic monophosphate …

CD74-AKT Axis Is a Potential Therapeutic Target in Triple-Negative Breast Cancer

J Wang, D Huang, TAT Nguyen, LM Phan, W Wei… - Biology, 2024 - mdpi.com
Simple Summary Triple-negative breast cancer is a highly aggressive type of invasive breast
cancer in which the patients frequently develop resistance to inhibitors used for induction of …

Peptides for diagnosis and treatment of colorectal cancer

S Shapira, A Fokra, N Arber… - Current medicinal …, 2014 - ingentaconnect.com
Colorectal cancer (CRC) is a major health concern worldwide, as it is the third most
frequently diagnosed cancer and the second leading cause of cancer-related death. There …

Natriuretic peptides: Another tool for the management of cancer?

J Balaguer, J Garcia-Foncillas, J Tunon - Critical Reviews in Oncology …, 2024 - Elsevier
The connection between heart failure (HF) and cancer through multiple pathways such as
inflammation, oxidative stress, and neurohormonal activation, among others, is well …

C Type Natriuretic Peptide Receptor Activation Inhibits Sodium Channel Activity in Human Aortic Endothelial Cells by Activating the Diacylglycerol-Protein Kinase C …

L Yu, MZ Nouri, LP Liu, N Bala, ND Denslow… - International Journal of …, 2022 - mdpi.com
The C-type natriuretic peptide receptor (NPRC) is expressed in many cell types and binds all
natriuretic peptides with high affinity. Ligand binding results in the activation or inhibition of …

Cardiac and renal hormones: anticancer effects in vitro and in vivo

DL Vesely - Journal of Investigative Medicine, 2009 - journals.sagepub.com
Background Four cardiovascular hormones, ie, vessel dilator, long-acting natriuretic peptide,
kaliuretic peptide, and atrial natriuretic peptide each at 1 mmol/L, decrease up to 97% of …

Cardiac hormones target nuclear oncogenes c‐F os and c‐J un in carcinoma cells

NJ Manimala, CD Frost, ML Lane… - European Journal of …, 2013 - Wiley Online Library
Background c‐F os is a cellular proto‐oncogene which dimerizes with c‐J un proto‐
oncogene to form AP‐1 transcription factor, which upregulates transcription of genes …