Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused
by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations …

This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …

Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of …

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …

Abstract The von Hippel–Lindau hereditary cancer syndrome was first described about 100
years ago. The unusual clinical features of this disorder predicted a role for the von Hippel …

Mutation of the VHL tumor suppressor is associated with the inherited von Hippel–Lindau
(VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC …

A partial cDNA sequence for the gene linked to the von Hippel–Lindau (VHL) syndrome was
reported in 1993. Mutation or loss of both VHL alleles has been documented in sporadic …

Pheochromocytoma is a rare but important tumor of chromaffin cells that is frequently
considered in the evaluation of hypertension, arrhythmias, or panic disorder and in the …

Cancer genetics has for many years focused on mutational events that have their primary
effect within the cancer cell. Recently that focus has widened, with evidence of the …