Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To
better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis …

Context It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain
symptomatic, but why patients are susceptible to this condition, why symptoms persist, and …

Thyroid hormones (THs), including T4 and T3, are produced and released by the thyroid
gland under the stimulation of thyroid-stimulating hormone (TSH). The homeostasis of THs is …

In thyroid health, the pituitary hormone thyroid-stimulating hormone (TSH) raises glandular
thyroid hormone production to a physiological level and enhances formation and conversion …

Primary congenital hypothyroidism (CH) is the most common endocrine disease in children
and one of the most common preventable causes of both cognitive and motor deficits. CH is …

Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus,
it is involved in a wide range of vital functions throughout the life cycle of all vertebrates …

The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such
as cellular metabolism, cell structure, and membrane transport. The therapeutic drugs …

Endocrine regulation in the hypothalamic-pituitary-thyroid (HPT) axis is orchestrated by
physiological circuits which integrate multiple internal and external influences. Essentially, it …