The human gut microbiome in health and disease
The harmonic coexistence of microorganisms with the human body is the result of a long
coevolutionary process that has minimized competition for nutrients and immunological …
coevolutionary process that has minimized competition for nutrients and immunological …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Long-primed germinal centres with enduring affinity maturation and clonal migration
Germinal centres are the engines of antibody evolution. Here, using human
immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed …
immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
[HTML][HTML] T follicular helper cell differentiation, function, and roles in disease
S Crotty - Immunity, 2014 - cell.com
Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are
essential for germinal center formation, affinity maturation, and the development of most high …
essential for germinal center formation, affinity maturation, and the development of most high …
Type I interferon in chronic virus infection and cancer
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …
Human circulating PD-1+ CXCR3− CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
The vast majority of currently licensed human vaccines work on the basis of long-term
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …
CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …