Enantioselective transition metal catalysis is an area very much at the forefront of
contemporary synthetic research. The development of processes that enable the efficient …

Conspectus Noncovalent interactions are ubiquitous in nature and are responsible for the
precision control in enzyme catalysis via the cooperation of multiple active sites. Inspired by …

Chiral phosphorus ligands have played a crucial role for the recent advances in asymmetric
catalysis. This review summarizes chiral phosphorus ligands developed from the Laboratory …

Abstract Bicyclo [1.1. 1] pentanes (BCPs) have sparked the interest of medicinal chemists
due to their recent discovery as bioisosteres of aromatic rings. To study the biological activity …

Ir-catalyzed asymmetric hydrogenation of quinolines was developed, and both enantiomers
of chiral tetrahydroquinoline derivatives could be easily obtained, respectively, in high yields …

Transition metal-catalyzed asymmetric hydrogenation (AH) of unprotected indoles has
mainly been applied to alkyl substituted unprotected indoles. However, the challenging aryl …

1, 4-Benzodioxane widely exists as the core structure in many therapeutic agents and
bioactive natural compounds. Hence, to access this kind of molecule, an enantioselective …

Chiral motifs of 2, 3-dihydro-1, 4 benzodioxane are extensively utilized in diverse medicinal
substances and bioactive natural compounds, exhibiting significant biological activities …

The Ir-catalyzed highly efficient asymmetric hydrogenation of benzoxazinones and
derivatives was successfully developed with N-methylated ZhaoPhos L5 as the ligand …

Herein, we report an efficient iridium-catalyzed double asymmetric hydrogenation of 2, 5-
dialkylienecyclopentanones, delivering the chiral 2, 5-disubstituted cyclopentanones in …