COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death
globally, and manifests as a progressive inflammatory lung disease with no curative …

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease
(COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression …

Rationale: Necroptosis, mediated by RIPK3 (receptor-interacting protein kinase 3) and
MLKL (mixed lineage kinase domain-like), is a form of regulated necrosis that can drive …

Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of
the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase …

Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …

Workers in the mining and construction industries are at increased risk of respiratory and
other diseases as a result of being exposed to harmful levels of airborne particulate matter …