Leukotrienes are potent immune-regulating lipid mediators with patho-genic roles in
inflammatory and allergic diseases, particularly asthma. These autacoids also contribute to …

Abstract Microsomal glutathione transferase 1 (MGST1) is a member of the MAPEG family
(membrane associated proteins in eicosanoid and glutathione metabolism), defined …

Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased
production of proinflammatory PGE 2 and can lead to shunting of PGH 2 into the …

Background Improving feed efficiency is the most important goal for modern animal
production. The regulatory mechanisms of controlling feed efficiency traits are extremely …

Membrane proteins are challenging targets to functionally and structurally characterize. An
enduring bottleneck in their study is the reliable production of sufficient yields of stable …

Glutathione transferases (GSTs) are a class of phase II detoxifying enzymes catalysing the
conjugation of glutathione (GSH) to endogenous and exogenous electrophilic molecules …

Xylene exposure is known to induce toxicity in hematopoietic stem and progenitor cells
(HSPCs), leading to bone marrow suppression and potential leukemogenesis. However …

Enzymes have flexible structures and can modulate the multiple catalytic sites efficiently for
synergistic catalysis. Inspired by enzymes, various artificial catalysts have been designed …

Glutathione transferases (GSTs) are the primary catalysts protecting from reactive
electrophile attack. In this review, the quantitative levels and distribution of glutathione …

At the very deepest molecular level, the mechanisms of life depend on the operation of
proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that …