[HTML][HTML] Don't fear 'fear conditioning': Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear

TB Lonsdorf, MM Menz, M Andreatta… - Neuroscience & …, 2017 - Elsevier
The so-called 'replicability crisis' has sparked methodological discussions in many areas of
science in general, and in psychology in particular. This has led to recent endeavours to …

Targeting human glucocorticoid receptors in fear learning: a multiscale integrated approach to study functional connectivity

S Battaglia, C Di Fazio, M Mazzà, M Tamietto… - International journal of …, 2024 - mdpi.com
Fear extinction is a phenomenon that involves a gradual reduction in conditioned fear
responses through repeated exposure to fear-inducing cues. Functional brain connectivity …

More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans-Biological, experiential, temperamental factors, and …

TB Lonsdorf, CJ Merz - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Why do only some individuals develop pathological anxiety following adverse events? Fear
acquisition, extinction and return of fear paradigms serve as experimental learning models …

Neurobiology of comorbid post‐traumatic stress disorder and alcohol‐use disorder

NW Gilpin, JL Weiner - Genes, Brain and Behavior, 2017 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

Sex differences in stress effects on emotional learning

CJ Merz, OT Wolf - Journal of Neuroscience Research, 2017 - Wiley Online Library
Stress influences emotional learning and memory processes. These effects are thought to
underlie stress‐associated mental disorders. Sex differences in stress reactivity and in …

Rodent models of impaired fear extinction

N Singewald, A Holmes - Psychopharmacology, 2019 - Springer
The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral
preparation that is nonetheless tractable, from a translational perspective, as an approach to …

[HTML][HTML] How stress hormones shape memories of fear and anxiety in humans

CJ Merz, OT Wolf - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Stress hormones influence the processing of fear, anxiety, and related memory mechanisms.
For example, they modulate consolidation and retrieval processes associated with …

Effects of 3, 4-methylenedioxymethamphetamine on conditioned fear extinction and retention in a crossover study in healthy subjects

P Vizeli, I Straumann, U Duthaler… - Frontiers in …, 2022 - frontiersin.org
Background: 3, 4-Methylenedioxymethamphetamine (MDMA) has shown initial promise as
an adjunct in psychotherapy to treat posttraumatic stress disorder (PTSD). Its efficacy and …

Threat response system: parallel brain processes in pain vis-à-vis fear and anxiety

I Elman, D Borsook - Frontiers in psychiatry, 2018 - frontiersin.org
Pain is essential for avoidance of tissue damage and for promotion of healing.
Notwithstanding the survival value, pain brings about emotional suffering reflected in fear …

Resilience: safety in the aftermath of traumatic stressor experiences

K Matheson, A Asokumar, H Anisman - Frontiers in behavioral …, 2020 - frontiersin.org
The relationship between adverse experiences and the emergence of pathology has often
focused on characteristics of the stressor or of the individual (stressor appraisals, coping …