Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many
parts of the world. The" obesity epidemic" appears to have emerged largely from changes in …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …

Insulin has long-term effects on glucose and lipid metabolism through its control on the
expression of specific genes. In insulin sensitive tissues and particularly in the liver, the …

Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate
(G6P), a step which is essential for glucose metabolism in liver as well as for the induction of …

The regulation of hepatic glucose metabolism has a key role in whole-body energy
metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce …

OBJECTIVE The global epidemic of metabolic syndrome and its complications demands
rapid evaluation of new and accessible interventions. Insulin resistance is the central …

Insulin resistant states are commonly associated with an atherogenic dyslipidemia that
contributes to significantly higher risk of atherosclerosis and cardiovascular disease. Indeed …

In this study, we investigated the role of acyl‐coenzyme A: diacylglycerol acyltransferase 2
(DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver …

The purpose of this review is to provide information about the role of exercise in the
prevention of skeletal muscle insulin resistance, that is, the inability of insulin to properly …