Microtubules: From understanding their dynamics to using them as potential therapeutic targets

Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

[HTML][HTML] mRNA targeting, transport and local translation in eukaryotic cells: from the classical view to a diversity of new concepts

KA Lashkevich, SE Dmitriev - Molecular Biology, 2021 - Springer
Spatial organization of protein biosynthesis in the eukaryotic cell has been studied for more
than fifty years, thus many facts have already been included in textbooks. According to the …

Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation

L Coutinho de Oliveira, L Volpon… - Proceedings of the …, 2019 - National Acad Sciences
Viruses have transformed our understanding of mammalian RNA processing, including
facilitating the discovery of the methyl-7-guanosine (m7G) cap on the 5′ end of RNAs. The …

Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex

L Dimitrova-Paternoga, PKA Jagtap… - Genes & …, 2021 - genesdev.cshlp.org
Kinesin-1 carries cargos including proteins, RNAs, vesicles, and pathogens over long
distances within cells. The mechanochemical cycle of kinesins is well described, but how …

Stress granule and P-body clearance: Seeking coherence in acts of disappearance

JR Buchan - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Stress granules and P-bodies are conserved cytoplasmic biomolecular condensates whose
assembly and composition are well documented, but whose clearance mechanisms remain …

[HTML][HTML] Microtubule-driven stress granule dynamics regulate inhibitory immune checkpoint expression in T cells

DM Franchini, O Lanvin, M Tosolini, EP de Campaigno… - Cell Reports, 2019 - cell.com
Despite the clinical success of blocking inhibitory immune checkpoint receptors such as
programmed cell death-1 (PD-1) in cancer, the mechanisms controlling the expression of …

Uncovering the role of cytoskeleton proteins in the formation of neutrophil extracellular traps

C Du, N Cai, J Dong, C Xu, Q Wang, Z Zhang… - International …, 2023 - Elsevier
Neutrophils are a type of lymphocyte involved in innate immune defense. In response to
specific stimuli, these phagocytic cells undergo a unique form of cell death, NETosis, during …

Molecular dissection of defense response of pears induced by the biocontrol yeast, Wickerhamomyces anomalus using transcriptomics and proteomics approaches

Q Zhang, L Zhao, B Li, X Gu, X Zhang, NS Boateng… - Biological Control, 2020 - Elsevier
Wickerhamomyces anomalus, a yeast used for the biocontrol of postharvest diseases of
fruits, significantly reduces the natural decay of pear fruit without causing any adverse …

Regulation of aquaporin‐4 expression in the central nervous system investigated using M23‐AQP4 null mouse

F Pisani, L Simone, MG Mola, M De Bellis, A Frigeri… - Glia, 2021 - Wiley Online Library
In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of
water channel aquaporin‐4 (M1‐AQP4 and M23‐AQP4). The ratio between these two …

Nanostructure of Functional Larotaxel Liposomes Decorated with Guanine‐Rich Quadruplex Nucleotide–Lipid Derivative for Treatment of Resistant Breast Cancer

X Li, J Li, J Xu, K Chen, Z Zhang, J Duan, Q Luo, Y Du… - Small, 2021 - Wiley Online Library
Breast cancer is the most common malignant disease in women all over the world and its
chemotherapy outcome is restricted by multidrug resistance. Here, a nanostructure by …