Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology
In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …
evolution, and systems/synthetic biology approaches employed in the production and …
Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world
JM Hagel, PJ Facchini - Plant and Cell Physiology, 2013 - academic.oup.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …
metabolites with a long history of investigation. Although the ecophysiological functions of …
Modular optimization of multi-gene pathways for fatty acids production in E. coli
Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-
based transportation fuels. Here we report a modular engineering approach that …
based transportation fuels. Here we report a modular engineering approach that …
Integrated omics analysis of specialized metabolism in medicinal plants
Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …
pharmacological properties. Until recently, plant biologists were limited in their ability to …
Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis
Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting
benefits. To date, plant extraction is still the primary route to produce high-value natural …
benefits. To date, plant extraction is still the primary route to produce high-value natural …
Compartmentalization and transporter engineering strategies for terpenoid synthesis
K Jin, H Xia, Y Liu, J Li, G Du, X Lv, L Liu - Microbial Cell Factories, 2022 - Springer
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-
friendly approach than chemical synthesis and extraction, and are thus being regarded as …
friendly approach than chemical synthesis and extraction, and are thus being regarded as …
DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …
scale, but some drawbacks still exist in this process, such as unstable intermediates …
Generation of structurally novel short carotenoids and study of their biological activity
Recent research interest in phytochemicals has consistently driven the efforts in the
metabolic engineering field toward microbial production of various carotenoids. In spite of …
metabolic engineering field toward microbial production of various carotenoids. In spite of …
Promoter-Library-Based Pathway Optimization for Efficient (2S)-Naringenin Production from p-Coumaric Acid in Saccharomyces cerevisiae
Pathway optimization plays an important role in fine-tuning metabolic pathways. In most
conditions, more than three genes are involved in the biosynthesis pathway of a specific …
conditions, more than three genes are involved in the biosynthesis pathway of a specific …
[HTML][HTML] New applications for phage integrases
Within the last 25 years, bacteriophage integrases have rapidly risen to prominence as
genetic tools for a wide range of applications from basic cloning to genome engineering …
genetic tools for a wide range of applications from basic cloning to genome engineering …