The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements
that generate the so-called RET/PTC oncogenes. In this review, we examine the data about …

Myeloproliferative neoplasms are frequently associated with aberrant constitutive tyrosine
kinase (TK) activity resulting from chimaeric fusion genes or point mutations such as BCR …

RET (REarranged during Transfection) is a transmembrane receptor tyrosine kinase that is
activated by a complex consisting of a soluble glial cell line‐derived neurotrophic factor …

We will highlight and put into perspective new lineage tracing data from genetic studies in
mice indicating that the genuine progenitors to C cells arise in the endoderm germ layer …

BACKGROUND AND AIMS: Vitamin D3, in addition to its role in calcium homeostasis, has
been recognized as playing a role in human cancer development. However, little is known …

Gain‐of‐function mutations within the receptor tyrosine kinase gene RET cause inherited
and non‐inherited thyroid cancer. Somatic gene rearrangements of RET have been found in …

Thyroid dysgenesis is the most common cause of congenital hypothyroidism that affects 1 in
3000 newborns. Although a number of pathogenetic mutations in thyroid developmental …

Context: RET is a tyrosine kinase transmembrane receptor expressed in two main
alternative isoforms: RET9 and RET51. RET transduces a positive signal leading to survival …