Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

RP Ceddia, Z Zurawski, AT Gray… - The Journal of …, 2023 - Am Soc Clin Investig
Negative regulation of exocytosis from secretory cells is accomplished through inhibitory
signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms: decreased calcium …

Understanding the nervous system: lessons from Frontiers in Neurophotonics

Y De Koninck, J Alonso, S Bancelin… - …, 2024 - spiedigitallibrary.org
The Frontiers in Neurophotonics Symposium is a biennial event that brings together
neurobiologists and physicists/engineers who share interest in the development of leading …

Higher Neuronal Facilitation and Potentiation with APOE4 Suppressed by Angiotensin II

SB Scheinman, KY Tseng, S Alford, LM Tai - Molecular neurobiology, 2024 - Springer
Progressive hippocampal degeneration is a key component of Alzheimer's disease (AD)
progression. Therefore, identifying how hippocampal neuronal function is modulated early in …

SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens

KM Manz, JC Zepeda, Z Zurawski, HE Hamm… - Frontiers in Cellular …, 2023 - frontiersin.org
The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in
pathological behavioral states, including addiction and depression. These behaviors …

Live Cell Light Sheet Imaging with Low-and High-Spatial-Coherence Detection Approaches Reveals Spatiotemporal Aspects of Neuronal Signaling

M Potcoava, D Contini, Z Zurawski, S Huynh, C Mann… - Journal of …, 2023 - mdpi.com
Light sheet microscopy in live cells requires minimal excitation intensity and resolves three-
dimensional (3D) information rapidly. Lattice light sheet microscopy (LLSM) works similarly …

Evaluating the Role of APOE Genotype in Modulating Hippocampal Angiotensin Type 1 Receptor Activity

S Scheinman - 2023 - search.proquest.com
With an aging population, AD is rapidly becoming a severe public health concern effecting
roughly 1 in 9 adults age 65 and older. The development of novel approaches to prevent …

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

RP Ceddia, Z Zurawski, AT Gray, F Adegboye… - bioRxiv, 2020 - biorxiv.org
Negative regulation of exocytosis from secretory cells throughout the body is accomplished
through inhibitory signals from Gi/o G protein-coupled receptors by Gβγ subunit inhibition of …