Importance Hypoxic-ischemic encephalopathy (HIE) occurs in 1 to 8 per 1000 live births in
developed countries. Historically, the clinician has had little to offer neonates with HIE other …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Objective To determine the effectiveness and safety of moderate whole-body hypothermia in
newborns with hypoxic-ischemic encephalopathy born in hospitals with and without …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …