Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

A Jordan, JA Hadfield, NJ Lawrence… - Medicinal research …, 1998 - Wiley Online Library
Tubulin is the biochemical target for several clinically used anticancer drugs, including
paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the …

Metabolites from symbiotic bacteria

J Piel - Natural product reports, 2009 - pubs.rsc.org
Metabolites from symbiotic bacteria - Natural Product Reports (RSC Publishing) DOI:10.1039/B703499G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …

[图书][B] Marine chemical ecology

JB McClintock, BJ Baker - 2001 - taylorfrancis.com
The interdisciplinary field of marine chemical ecology is an expanding and dynamic science.
It is no surprise that the breadth of marine organisms studied expanded in concert with …

Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals

J Piel - Current medicinal chemistry, 2006 - ingentaconnect.com
Invertebrate animals, such as sponges, tunicates and bryozoans, are among the most
important sources of biomedically relevant natural products. However, as these animals …

The biosynthesis of marine natural products

MJ Garson - Chemical reviews, 1993 - ACS Publications
This article is written as an overview of current marine biosynthetic knowledge and as an
extension of previous reviews in which the biosynthetic origins of marine natural products …

Evidence for a symbiosis between bacteria of the genus Rhodobacter and the marine sponge Halichondria panicea : harbor also for putatively toxic bacteria?

K Althoff, C Schütt, R Steffen, R Batel, WEG Mueller - Marine Biology, 1998 - Springer
Halichondria panicea (Pallas) is a marine sponge, abundantly occurring in the Adriatic Sea,
North Sea, and Baltic Sea. It was the aim of the present study to investigate if this sponge …

Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller)

AE Flowers, MJ Garson, RI Webb, EJ Dumdei… - Cell and tissue …, 1998 - Springer
The tropical marine sponge Dysidea herbacea (Keller) contains the filamentous unicellular
cyanobacterium Oscillatoria spongeliae (Schulze) Hauck as an endosymbiont, plus …

Microbes from marine sponges: a treasure trove of biodiversity for natural products discovery

RT Hill - Microbial diversity and bioprospecting, 2003 - Wiley Online Library
Microbes associated with marine sponges are of interest in marine biotechnology for several
reasons. Sponge‐associated microbes are a resource for drug discovery. Studies on the …

Application of Cell Culture for the Production of Bioactive Compounds from Sponges:  Synthesis of Avarol by Primmorphs from Dysidea avara

WEG Müller, M Böhm, R Batel, S De Rosa… - Journal of Natural …, 2000 - ACS Publications
Among all metazoan phyla, sponges are known to produce the largest number of bioactive
compounds. However, until now, only one compound, arabinofuranosyladenine, has been …

Distribution of brominated compounds within the sponge Aplysina aerophoba: coupling of X-ray microanalysis with cryofixation techniques

X Turon, MA Becerro, MJ Uriz - Cell and Tissue Research, 2000 - Springer
The major secondary metabolites of the sponge Aplysina aerophoba are brominated
compounds. X-ray energy dispersive microanalysis was therefore used to locate secondary …