Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Metastasis is the major driver of death in patients with cancer. Invasion of surrounding
tissues and metastasis have been proposed to initiate following loss of the intercellular …

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …

Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular
traps (NETs). These are pathogen-trapping structures generated by expulsion of the …

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves
response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 …

Intratumoral CD103+ dendritic cells (DCs) are necessary for anti-tumor immunity. Here we
evaluated the expression of immune regulators by CD103+ DCs in a murine model of breast …

Carcinomas typically invade as a cohesive multicellular unit, a process termed collective
invasion. It remains unclear how different subpopulations of cancer cells contribute to this …

Natural killer (NK) cells have potent antitumor and antimetastatic activity. It is incompletely
understood how cancer cells escape NK cell surveillance. Using ex vivo and in vivo models …

Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC), which faithfully reports expression of p16 INK4a, a …