The addition of an allylic organometallic compound to a carbonyl compound or an imine is of
great synthetic interest because in this reaction together with a new functionality (hydroxyl or …

Due to the unusual structure and chemical composition of the mycobacterial cell wall,
effective tuberculosis (TB) treatment is difficult, making many antibiotics ineffective and …

Antimalarial bioassay-guided fractionation of an EtOH extract of the root wood of
Cryptocarya rigidifolia (Lauraceae) led to the isolation of the five new 5, 6-dihydro-α-pyrones …

The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve
triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products …

Background: Treatment of leishmaniasis is a challenge due to problems such as high price
and dose of the drug, drug resistance and side effects. Objective: The study aims to …

Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids
derivatives with aliphatic alcohols. Structures of the products were elucidated by …

The first asymmetric convergent total synthesis of four isomers of proposed structures of
cryptorigidifoliol K (1a, 1b, 1c, and 1d) has been achieved from commercially available …

Background: Visceral leishmaniasis is a complex neglected tropical disease caused by
Leishmania donovani complex. Its current treatment reveals strong limitations, especially …

The present study examines a set of 43 compounds for their antileishmanial activities and
cytotoxicities. Negative lowest unoccupied molecular orbitas and similar values for the …

Six enantiomeric pairs of β-aryl-δ-iodo-γ-lactones 8a–c, 9a–c derived from cuminaldehyde,
2, 5-dimethylbenzaldehyde and piperonal were synthesized with high enantiomeric purities …