This perspective discusses the role of pregnane xenobiotic receptor (PXR) in drug discovery
and the impact of its activation on CYP3A4 induction. The use of structural biology to reduce …

Being in the center of both therapeutic and toxicological concerns, NRs are widely studied
for drug discovery application but also to unravel the potential toxicity of environmental …

Triazophos (TAP) was a widely used organophosphorus insecticide in developing countries.
TAP could produce specific metabolites triazophos-oxon (TAPO) and 1-phenyl-3-hydroxy-1 …

Receptor-mediated molecular initiating events (MIEs) and their relevance in endocrine
activity (EA) have been highlighted in literature. More than 15 receptors have been …

Backgrounds Polychlorinated biphenyls are persistent environmental pollutants associated
with the onset of non-alcoholic fatty liver disease in humans, but there is limited information …

2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound
contaminating the environment and affecting human/animal health and reproduction …

Nuclear receptors (NRs) are ligand-modulated transcription factors that regulate multiple
physiological functions in our body. Many NRs in their unliganded state are localized in the …

Environmental pollutants, particularly persistent organic pollutants but also widespread short-
lived ones (bisphenol family and phthalates), also may be endocrine disruptors. These …

Exposure to environmental pollutants can modulate many biological and molecular
processes such as gene expression, gene repair mechanisms, hormone production and …