Designing out PXR activity on drug discovery projects: a review of structure-based methods, empirical and computational approaches
A Hall, H Chanteux, K Ménochet… - Journal of Medicinal …, 2021 - ACS Publications
This perspective discusses the role of pregnane xenobiotic receptor (PXR) in drug discovery
and the impact of its activation on CYP3A4 induction. The use of structural biology to reduce …
and the impact of its activation on CYP3A4 induction. The use of structural biology to reduce …
Review of in silico studies dedicated to the nuclear receptor family: Therapeutic prospects and toxicological concerns
Being in the center of both therapeutic and toxicological concerns, NRs are widely studied
for drug discovery application but also to unravel the potential toxicity of environmental …
for drug discovery application but also to unravel the potential toxicity of environmental …
Assessment of the endocrine-disrupting effects of organophosphorus pesticide triazophos and its metabolites on endocrine hormones biosynthesis, transport and …
FW Yang, YX Li, FZ Ren, J Luo, GF Pang - Food and chemical toxicology, 2019 - Elsevier
Triazophos (TAP) was a widely used organophosphorus insecticide in developing countries.
TAP could produce specific metabolites triazophos-oxon (TAPO) and 1-phenyl-3-hydroxy-1 …
TAP could produce specific metabolites triazophos-oxon (TAPO) and 1-phenyl-3-hydroxy-1 …
Predicting endocrine disruption using conformal prediction–a prioritization strategy to identify hazardous chemicals with confidence
M Sapounidou, U Norinder… - Chemical Research in …, 2022 - ACS Publications
Receptor-mediated molecular initiating events (MIEs) and their relevance in endocrine
activity (EA) have been highlighted in literature. More than 15 receptors have been …
activity (EA) have been highlighted in literature. More than 15 receptors have been …
Transcriptome analysis in normal human liver cells exposed to 2, 3, 3′, 4, 4′, 5-Hexachlorobiphenyl (PCB 156)
N Chen, Q Shan, Y Qi, W Liu, X Tan, J Gu - Chemosphere, 2020 - Elsevier
Backgrounds Polychlorinated biphenyls are persistent environmental pollutants associated
with the onset of non-alcoholic fatty liver disease in humans, but there is limited information …
with the onset of non-alcoholic fatty liver disease in humans, but there is limited information …
Proteomic changes of aryl hydrocarbon receptor (AhR)-silenced porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
K Orlowska, S Swigonska, A Sadowska… - Plos One, 2019 - journals.plos.org
2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound
contaminating the environment and affecting human/animal health and reproduction …
contaminating the environment and affecting human/animal health and reproduction …
Detection of endocrine and metabolism disrupting xenobiotics in milk-derived fat samples by fluorescent protein-tagged nuclear receptors and live cell imaging
K Thakur, ESK Goud, Y Jawa, C Keswani… - Toxicology …, 2023 - Taylor & Francis
Nuclear receptors (NRs) are ligand-modulated transcription factors that regulate multiple
physiological functions in our body. Many NRs in their unliganded state are localized in the …
physiological functions in our body. Many NRs in their unliganded state are localized in the …
Role of mixtures of organic pollutants in the development of metabolic disorders via the activation of xenosensors
M Aggerbeck, EB Blanc - Current Opinion in Toxicology, 2018 - Elsevier
Environmental pollutants, particularly persistent organic pollutants but also widespread short-
lived ones (bisphenol family and phthalates), also may be endocrine disruptors. These …
lived ones (bisphenol family and phthalates), also may be endocrine disruptors. These …
[PDF][PDF] Environmental pollutants-dependent molecular pathways and carcinogenesis
M El Helou, PA Cohen, M Diab-Assaf… - …, 2019 - biodiscovery.pensoft.net
Exposure to environmental pollutants can modulate many biological and molecular
processes such as gene expression, gene repair mechanisms, hormone production and …
processes such as gene expression, gene repair mechanisms, hormone production and …