Engineering selectively targeting antimicrobial peptides

M Lei, A Jayaraman, JA Van Deventer… - Annual review of …, 2021 - annualreviews.org
The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the
development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds …

Thinking on the construction of antimicrobial peptide databases: Powerful tools for the molecular design and screening

K Zhang, D Teng, R Mao, N Yang, Y Hao… - International Journal of …, 2023 - mdpi.com
With the accelerating growth of antimicrobial resistance (AMR), there is an urgent need for
new antimicrobial agents with low or no AMR. Antimicrobial peptides (AMPs) have been …

The methods of digging for “Gold” within the salt: characterization of halophilic prokaryotes and identification of their valuable biological products using sequencing …

J Lach, P Jęcz, D Strapagiel, A Matera-Witkiewicz… - Genes, 2021 - mdpi.com
Halophiles, the salt-loving organisms, have been investigated for at least a hundred years.
They are found in all three domains of life, namely Archaea, Bacteria, and Eukarya, and …

Therapeutic Potential of Novel Mastoparan-Chitosan Nanoconstructs Against Clinical MDR Acinetobacter baumannii: In silico, in vitro and in vivo Studies

A Hassan, A Ikram, A Raza, S Saeed… - International Journal …, 2021 - Taylor & Francis
Purpose Acinetobacter baumannii antibiotic resistant infections in high-risk patients are a
great challenge for researchers and clinicians worldwide. In an effort to achieve potent …

Octopromycin: Antibacterial and antibiofilm functions of a novel peptide derived from Octopus minor against multidrug-resistant Acinetobacter baumannii

DC Rajapaksha, EHTT Jayathilaka… - Fish & Shellfish …, 2021 - Elsevier
The emergence of carbapenem-resistant Acinetobacter baumannii has increased the risk of
nosocomial infections, which pose a huge health threat. There is an urgent need to develop …

Bioinformatics design of a peptide vaccine containing sarcoma antigen NY-SAR-35 epitopes against breast cancer and evaluation of its immunological function in …

N Samman, H Mohabatkar, M Behbahani… - Plos one, 2024 - journals.plos.org
The development of a cancer vaccine has become an essential focus in the field of medical
biotechnology and immunology. In our study, the NY-SAR-35 cancer/testis antigen was …

Engineering Strategies for Discovering Antimicrobial Therapeutics

M Lei - 2022 - search.proquest.com
The gut microbiota is a community of microbial species that contributes to important
metabolic functions that critically impact human health. A significant perturbation to the …