Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

The cytosol-localised mevalonic acid (MVA) pathway delivers the basic isoprene unit
isopentenyl diphosphate (IPP). In higher plants, this central metabolic intermediate is also …

The biosynthesis of natural products by heterologous expression of biosynthetic pathways in
amenable production strains enables biotechnological access to a variety of valuable …

Cell-free metabolic engineering (CFME) is advancing a powerful paradigm for accelerating
the design and synthesis of biosynthetic pathways. However, as most cell-free biomolecule …

Abstract Plants have evolved the capacity to produce a striking array of specialised
metabolites. Terpenoids are the oldest and most diverse class of such compounds and have …

Isoprenoids are an attractive class of metabolites for enzymatic synthesis from renewable
substrates. However, metabolic engineering of microorganisms for monoterpenoid …

Highlights•Plant metabolic pathways can be reconstituted in heterologous
hosts.•Metabolism in crop plants can be engineered to improve the production of …

Since time immemorial, human use medicinal plants as sources of food, therapy and
industrial purpose. Classical biotechnology and recent next-generation sequencing (NGS) …

Catalyzing stereo-and regio-specific oxidation of inert hydrocarbon backbones, and a range
of more exotic reactions inherently difficult in formal chemical synthesis, cytochromes P450 …

Natural products are a group of bioactive structurally diverse chemicals produced by
microorganisms and plants. These molecules and their derivatives have contributed to over …