Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Cytosolic delivery of proteins and peptides provides opportunities for effective disease
treatment, as they can specifically modulate intracellular processes. However, most of …

Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

Oxidative stress and cell senescence are both important drivers of ageing and age-
associated disease and disability. In vitro, they are closely interconnected in a chicken-and …

Supramolecular peptide hydrogels (SPHs) consist of peptides containing hydrogelators and
functional epitopes, which can first self-assemble into nanofibers and then physically …

Abdominal aortic aneurysm (AAA), a life-threatening pathological dilation of the abdominal
aorta, is characterized by chronic inflammation and extracellular matrix degradation. While …

Intracellular polymerization in living cells motivated chemists to generate polymeric
structures with a multitude of possibilities to interact with biomacromolecules. However, out …

Recent emphasis on the design of drug delivery systems typically involves the effective
transport of a pharmaceutical substance to the disease site with the desired therapeutic …

This work presents the design and synthesis of a functional epoxide monomer, 2-
(benzylthio) ethyl glycidyl ether (BTGE), serving as a versatile building block for the …