Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia
JA Siddiqui, R Pothuraju, P Khan, G Sharma… - Cytokine & growth factor …, 2022 - Elsevier
Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a
divergent member of the transforming growth factor β superfamily and has a diverse …
divergent member of the transforming growth factor β superfamily and has a diverse …
[HTML][HTML] Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis
Obesity and related metabolic dysregulation are risk factors for many types of cancer. The
interactions between a developing tumor and its microenvironment are known to implicate a …
interactions between a developing tumor and its microenvironment are known to implicate a …
Assessing sarcoma cell cytoskeleton remodeling in response to varying collagen concentration
K Polemidiotou, SG Kulkarni, R Szydlak… - International Journal of …, 2024 - Elsevier
Sarcomas, rare malignant tumors of mesenchymal origin, are often underdiagnosed and
have face diagnostic ambiguities and limited treatment options. The main objective of this …
have face diagnostic ambiguities and limited treatment options. The main objective of this …
Growth differentiation factor-15 overexpression promotes cell proliferation and predicts poor prognosis in cerebral lower-grade gliomas correlated with hypoxia and …
Y Wang, J Chen, C Chen, H Peng, X Lin, Q Zhao… - Life Sciences, 2022 - Elsevier
Aims Growth differentiation factor-15 (GDF15) plays complex and controversial roles in
cancer. In this study, the prognostic value and the exact biological function of GDF15 in …
cancer. In this study, the prognostic value and the exact biological function of GDF15 in …
Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis
M Sugimoto, R Suzuki, Y Nozawa, T Takagi… - Cancer Cell …, 2022 - Springer
Background Biliary tract cancer (BTC) has a poor prognosis; therefore, useful biomarkers
and treatments are needed. Serum levels of macrophage inhibitory cytokine-1 (MIC-1), a …
and treatments are needed. Serum levels of macrophage inhibitory cytokine-1 (MIC-1), a …
Construction and Identification of Eukaryotic Expression Vector pEGFP‐N1‐MIC‐1 for Mouse MIC‐1 Gene and Its Effect on Gastric Cancer Cells
HP Zhang, Z Qin, SS Shi, YF Li, Y Song… - Analytical Cellular …, 2024 - Wiley Online Library
This study aimed to construct an eukaryotic expression vector, pEGFP‐N1‐MIC‐1, for
overexpressing the mouse macrophage inhibitory cytokine‐1 (MIC‐1) gene. Additionally, we …
overexpressing the mouse macrophage inhibitory cytokine‐1 (MIC‐1) gene. Additionally, we …
Identification of potential crucial genes associated with breast cancer using bioinformatics analysis and experimental verification
X Ni, H Yang, C Liu - 2023 - researchsquare.com
In this study, we identified a total of 492 DEGs, including 176 up-regulated and 316 down-
regulated DEGs. GO analysis showed that the up-regulated DEGs are mainly involved in cell …
regulated DEGs. GO analysis showed that the up-regulated DEGs are mainly involved in cell …
Analysis of function and signaling pathway of guanine nucleotide exchange factor DOCK1 in acute myeloid leukemia
F Fuchs - 2020 - ediss.sub.uni-hamburg.de
Acute myeloid leukemia (AML) is a malignant disease of the hematopoietic system and is
characterized by immature myeloid cell proliferation, leading to bone marrow failure. Despite …
characterized by immature myeloid cell proliferation, leading to bone marrow failure. Despite …