Microglia play key roles in brain development, homeostasis, and function, and it is widely
assumed that the adult population is long lived and maintained by self-renewal. However …

Human labour is an inflammatory event, physiologically driven by an interaction between
hormonal and mechanical factors and pathologically associated with infection, bleeding and …

This study aimed to determine the mechanism of uterine activation during labour, both term
(TL) and preterm (PTL). We hypothesized that the peripheral leucocytes are recruited to …

Current therapies for preterm labour (PTL) focus on arresting myometrial contractions but
are largely ineffective, thus alternative therapeutic targets need to be identified. Leukocytes …

Parturition is associated with a leukocyte influx into the intrauterine tissues; however, the
exact role these leukocytes play in the onset of labor remains unclear. Neutrophil infiltration …

The expansion of the microglial population is one of the hallmarks of numerous brain
disorders. The addition of circulating progenitors to the pool of brain macrophages can …

Here we fully characterize the cytokine profile of laboring human myometrium using
Luminex analysis of 48 cytokine proteins, and stereologically quantified infiltration of …

Objectives To study the influence of pregnancy and labor on the proportion and level of
activation of monocyte subpopulations in human pregnancy. Study Design Peripheral blood …

During pregnancy and lactation, the uterus and mammary glands undergo remarkable
structural changes to perform their critical reproductive functions before reverting to their …

In our earlier work, we found that intrauterine (iu) and intraperitoneal (ip) injection of LPS (10-
μg serotype 0111: B4) induced preterm labor (PTL) with high pup mortality, marked systemic …