▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

Leptin (from the Greek leptos= thin) was identified only 3 years ago. It has attracted huge
attention both scentifically, with more than 600 publications, and in the media, where this …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

The discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent …

We summarize the biological impact of leptin signaling as well as the molecular and cellular
characteristics of leptin action. Our focus is principally in the central nervous system and we …

Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells:
Potential role in glomerulosclerosis. Background Leptin inhibits food intake and increases …

The prevalence of obesity (body mass index [BMI] 30 kg/m2) has risen to epidemic
proportions and continues to be a major health problem worldwide. 1–3 The high …

Leptin is a small peptide hormone that is mainly, but not exclusively, produced in adipose
tissue. The circulating leptin concentration therefore directly reflects the amount of body fat …

The uremic syndrome is a complex mixture of organ dysfunctions, which is attributed to the
retention of a myriad of compounds that under normal condition are excreted by the healthy …

▪ Abstract About 40% of patients undergoing maintenance dialysis suffer from varying
degrees of protein-energy malnutrition. This is a problem of substantial importance because …