The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Angiogenesis, the formation of new blood vessels from existing vessels, plays an important
role during development. In the adult, it is limited to the female reproductive system and to …

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

Regardless of the event that stimulates the aggregation of platelets, the receptor α llb β 3-
one of a family of adhesion receptors known as integrins–has a key role in the process. The …

Traditional drug delivery strategies involve drugs which are not targeted towards the desired
tissue. This can lead to undesired side effects, as normal cells are affected by the drugs as …

The diameter of resistance arteries has a profound effect on the distribution of microvascular
blood flow and the control of systemic blood pressure. Here, we review mechanisms that …

Vascular development and maturation are dependent on the interactions of endothelial cell
integrins with surrounding extracellular matrix. Previous investigations of the primacy of …

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a
fundamental process during cancer progression. Anti-angiogenic strategies have been …

Integrin αvβ3 has an important role in the proliferation, survival, invasion and migration of
vascular endothelial cells 1, 2. Like other integrins, αvβ3 can exist in different functional …