Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
[HTML][HTML] A model for RAS mutation patterns in cancers: finding the sweet spot
S Li, A Balmain, CM Counter - Nature Reviews Cancer, 2018 - nature.com
The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …
[HTML][HTML] Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling
Y Hayakawa, K Sakitani, M Konishi, S Asfaha… - Cancer cell, 2017 - cell.com
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …
[HTML][HTML] Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
P Storz - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
[HTML][HTML] Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively
in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base …
in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base …
[HTML][HTML] KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
[HTML][HTML] Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche
Y Hayakawa, H Ariyama, J Stancikova, K Sakitani… - Cancer cell, 2015 - cell.com
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain.
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …
Carcinogenesis of pancreatic ductal adenocarcinoma
P Storz, HC Crawford - Gastroenterology, 2020 - Elsevier
Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is
more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop …
more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop …
Neat1 is a p53-inducible lincRNA essential for transformation suppression
The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor
suppressor. Although p53 is a transcriptional activator that induces myriad target genes …
suppressor. Although p53 is a transcriptional activator that induces myriad target genes …