The genetic architecture of antidepressant response is poorly understood. Polygenic risk
scores (PRS), exploration of placebo response and the use of sub-scales might provide …

The increasing availability of biobanks is changing the way individuals are identified for
genomic research. This study assesses the validity of a self-reported clinical diagnosis of …

Most current approaches to establish subgroups of depressed patients for precision
medicine aim to rely on biomarkers that require highly specialized assessment. Our present …

Background Accurately predicting the probability of aggressive behavior is crucial for
guiding early intervention in patients with mood disorders. Methods Cox stepwise regression …

Objective The burden of major depressive disorder is compounded by a limited
understanding of its risk factors, the limited efficacy of treatments, and the lack of precision …

Introduction We report further validation and normative data for the THINC‐Integrated Tool
(THINC‐it), a measure of cognitive function designed for use with individuals living with …

MAP3K15 has been previously associated with protection from type 2 diabetes (T2D),
prompting interest in the development of MAP3K15 inhibitors as a potential therapeutic …

Background: The amygdala is crucial for emotional cognitive processing. Affective or
emotional states can bias cognitive processes, including attention, memory, and decision …

Objective Mood disorder (including major depression and bipolar disorder) prevalence is
over 10% and accounts for a significant share of global disease burden. Mental and physical …

Psychological trauma has been associated with an increased risk for a range of mental
disorders but its potential role as a transdiagnostic risk factor has not been systematically …