The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

Major trauma to the mammalian spinal cord often results in irreversible loss of function, ie
paralysis, and current therapies ranging from drugs, implantations of stem cells and/or …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

The ability of injured axons to regenerate declines with age, yet the mechanisms that
regulate axon regeneration in response to age are not known. Here we show that axon …

Microtubule dynamics in neurons play critical roles in physiology, injury and disease and
determine microtubule orientation, the cell biological correlate of neurite polarization …

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult
mammals. We used a genome-wide loss-of-function screen for factors limiting axonal …

Neurodegeneration has been correlated with mitochondrial DNA (mtDNA) damage and
exposure to environmental toxins, but causation is unclear. We investigated the ability of …

The shape of an individual neuron is linked to its function with axons sending signals to
other cells and dendrites receiving them. Although much is known of the mechanisms for …

Abstract Fibroblast growth factor 13 (FGF13), a nonsecretory protein of the FGF family, plays
a crucial role in developing cortical neurons by stabilizing the microtubule. In previous …

Hydra vulgaris is an emerging model organism for neuroscience due to its small size,
transparency, genetic tractability, and regenerative nervous system; however, fundamental …