Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and
catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via …

The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …

Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

With the advent of population aging, aging-related diseases have become a challenge for
governments worldwide. Sarcopenia has defined as a clinical syndrome associated with …

Background Age‐associated sarcopenia is characterized of progressed loss of skeletal
muscle power, mass, and function, which affects human physical activity and life quality …

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

Background The molecular mechanisms underlying denervated skeletal muscle atrophy
with concomitant muscle mass loss have not been fully elucidated. Therefore, this study …

Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and
dysfunction of the denervated muscles, but the underlying mechanism is not fully …

Duchenne muscular dystrophy (DMD) is a degenerative lethal, X-linked disease of skeletal
and cardiac muscles caused by mutations in the dystrophin gene. Cell therapy using …

Skeletal muscle atrophy is a debilitating condition that occurs with aging and disease, but
the underlying mechanisms are incompletely understood. Previous work determined that …