Chronic pancreatitis

J Kleeff, DC Whitcomb, T Shimosegawa… - Nature reviews Disease …, 2017 - nature.com
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the
pancreas in individuals with genetic, environmental and/or other risk factors who develop …

Genetics, cell biology, and pathophysiology of pancreatitis

J Mayerle, M Sendler, E Hegyi, G Beyer, MM Lerch… - Gastroenterology, 2019 - Elsevier
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Chronic pancreatitis

S Majumder, ST Chari - The Lancet, 2016 - thelancet.com
Chronic pancreatitis describes a wide spectrum of fibro-inflammatory disorders of the
exocrine pancreas that includes calcifying, obstructive, and steroid-responsive forms. Use of …

American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines

DL Conwell, LS Lee, D Yadav, DS Longnecker… - Pancreas, 2014 - journals.lww.com
The diagnosis of chronic pancreatitis remains challenging in early stages of the disease.
This report defines the diagnostic criteria useful in the assessment of patients with suspected …

Drug-induced acute pancreatitis: a review

MR Jones, OM Hall, AM Kaye, AD Kaye - Ochsner Journal, 2015 - ochsnerjournal.org
Background The majority of drug-induced pancreatitis cases are mild to moderate in
severity, but severe and even fatal cases can occur. Management of drug-induced …

Epidemiology of recurrent acute and chronic pancreatitis: similarities and differences

JD Machicado, D Yadav - Digestive diseases and sciences, 2017 - Springer
Emerging data in the past few years suggest that acute, recurrent acute (RAP), and chronic
pancreatitis (CP) represent a disease continuum. This review discusses the similarities and …

Genetic risk factors for pancreatic disorders

DC Whitcomb - Gastroenterology, 2013 - Elsevier
A combination of genetic, environmental, and metabolic factors contribute to the
development and recurrence of acute and chronic pancreatitis; information on all of these is …

Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis

GA Coté, D Yadav, A Slivka, RH Hawes… - Clinical …, 2011 - Elsevier
BACKGROUND & AIMS:: Alcohol has been implicated in the development of chronic
pancreatitis (CP) in 60%–90% patients, although percentages in the United States are not …

[HTML][HTML] Genetic risk in chronic pancreatitis: the trypsin-dependent pathway

E Hegyi, M Sahin-Tóth - Digestive diseases and sciences, 2017 - Springer
Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

The role of alcohol and smoking in pancreatitis

D Yadav, DC Whitcomb - Nature reviews Gastroenterology & …, 2010 - nature.com
Chronic alcohol use has been linked to chronic pancreatitis for over a century, but it has not
been until the last decade that the role of alcohol in chronic pancreatitis has been elucidated …