On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and …

DB Kell, E Pretorius - Integrative Biology, 2015 - academic.oup.com
We have recently highlighted (and added to) the considerable evidence that blood can
contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus …

[HTML][HTML] Individuality, phenotypic differentiation, dormancy and 'persistence'in culturable bacterial systems: commonalities shared by environmental, laboratory, and …

D Kell, M Potgieter, E Pretorius - F1000Research, 2015 - ncbi.nlm.nih.gov
For bacteria, replication mainly involves growth by binary fission. However, in a very great
many natural environments there are examples of phenotypically dormant, non-growing …

Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction

R Pandolfi, B Barreira, E Moreno, V Lara-Acedo… - Thorax, 2017 - thorax.bmj.com
Background Pulmonary hypertension (PH) is frequently observed in patients with acute
respiratory distress syndrome (ARDS) and it is associated with an increased risk of mortality …

Anti-inflammatory and anti-bacterial effects of iron chelation in experimental sepsis

S Islam, S Jarosch, J Zhou… - journal of surgical …, 2016 - Elsevier
Background Sepsis is the systemic inflammatory response to an infection. Generation of
reactive oxygen species represents an important part of the inflammatory cascade in sepsis …

Metabolomics and biomarkers for drug discovery

PK Yeung - Metabolites, 2018 - mdpi.com
Metabolomics and biomarkers are increasingly used in drug discovery and development,
and are applied to personalized medicine. Progress in these research areas has increased …

Novel relationships between oxidative stress and angiogenesis-related factors in sepsis: New biomarkers and therapies

S Vera, R Martinez, JG Gormaz, A Gajardo… - Annals of …, 2015 - Taylor & Francis
Sepsis is a systemic uncontrolled inflammatory response in the presence of an infection. It
remains a major cause of morbidity and mortality in hospitalized patients. According to its …

Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis

V Deckert, S Lemaire, PJ Ripoll, JPP de Barros… - Scientific Reports, 2017 - nature.com
Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the
context of atherosclerosis, it shares homology with proteins involved in innate immunity …

Engineered extracellular vesicles coated with an antimicrobial peptide for advanced control of bacterial sepsis

UH Ibrahim, MA Gafar, R Khan… - Journal of …, 2024 - Wiley Online Library
Alarming sepsis‐related mortality rates present significant challenges to healthcare services
globally. Despite advances made in the field, there is still an urgent need to develop …

Beneficial effects of omega-3 supplement to the enteral feeding in children with mild to moderate sepsis

MAM Al-Biltagi, AAEB Abo-Elezz… - Journal of Intensive …, 2017 - journals.sagepub.com
Objective: The objective was to investigate the benefits of supplementing enteral feeding
with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute …

Cell-selective pore forming antimicrobial peptides of the prodomain of human furin: A conserved aromatic/cationic sequence mapping, membrane disruption, and …

S Sinha, MK Harioudh, RP Dewangan, WJ Ng… - ACS …, 2018 - ACS Publications
Antimicrobial peptides are promising molecules in uprising consequences of drug-resistant
bacteria. The prodomain of furin, a serine protease, expressed in all vertebrates including …