[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

Cannabis use and cannabis use disorder

JP Connor, D Stjepanović, B Le Foll, E Hoch… - Nature Reviews …, 2021 - nature.com
Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …

Review of the endocannabinoid system

HC Lu, K Mackie - Biological Psychiatry: Cognitive Neuroscience and …, 2021 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Therapeutic potential of cannabis, cannabidiol, and cannabinoid-based pharmaceuticals

CA Legare, WM Raup-Konsavage, KE Vrana - Pharmacology, 2022 - karger.com
Background: There is a growing interest in the use of cannabis (and its extracts), as well as
CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is …

History of cannabis and the endocannabinoid system

MA Crocq - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
This article retraces the story of cannabis from the earliest contacts of humans with the plant
to its subsequent global expansion, its medicinal uses, and the discovery of the …

Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

[HTML][HTML] Cannabidiol (CBD) as a promising anti-cancer drug

ES Seltzer, AK Watters, D MacKenzie, LM Granat… - Cancers, 2020 - mdpi.com
Recently, cannabinoids, such as cannabidiol (CBD) and Δ 9-tetrahydrocannabinol (THC),
have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a …

[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …