Genome-wide association studies (GWASs) have transformed the field of human genetics
and have led to the discovery of hundreds of genes that are implicated in human disease …

Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

Inexpensive genotyping methods are essential for genetic studies requiring large sample
sizes. In human studies, array-based microarrays and high-density haplotype reference …

The house mouse, Mus musculus, was established in the early 1900s as one of the first
genetic model organisms owing to its short generation time, comparatively large litters, ease …

Structural variation is widespread in mammalian genomes, and is an important cause of
disease, but just how abundant and important structural variants (SVs) are in shaping …

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to
mapping populations able to deliver gene-level mapping resolution and the need for …

Genetic mapping on fully sequenced individuals is transforming understanding of the
relationship between molecular variation and variation in complex traits. Here we report a …

Intragenomic conflicts arise when a genetic element favours its own transmission to the
detriment of others. Conflicts over sex chromosome transmission are expected to have …

How Genes Influence Behavior takes a personal and lively approach to the study of
behavioral genetics, providing an up-to-date and accessible introduction to a variety of …

Although mice are the most widely used mammalian model organism, genetic studies have
suffered from limited mapping resolution due to extensive linkage disequilibrium (LD) that is …